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In a study published in Food and Chemical Toxicology and reported by Surviving Mesothelioma, a team of Korean cancer researchers found more evidence of the cancer-fighting power of resveratrol. Resveratrol is a natural phenol found in the skin of red grapes and plentiful in red wine and dark grape juice. It has been the subject of numerous cancer studies, but the Korean team was the first to study its effect specifically in mesothelioma. According to their new research, when resveratrol is used along with clofarabine, a drug typically used to treat acute lymphoblastic leukemia, the two have a "strong cytotoxic effect” on mesothelioma cells. Mesothelioma cells treated with both compounds accumulated higher levels of the tumor suppressor p53 in their nuclei, triggering apoptosis (cell death). The effect was not seen in healthy mesothelial cells.
In a summary of their findings, the study’s authors write, "These results demonstrate that resveratrol and clofarabine synergistically elicit apoptotic signal via a p53-dependent pathway and provide a scientific rationale for clinical evaluation of resveratrol as a promising chemopotentiator in malignant mesothelioma.”
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